|
KMID : 0043319920150030208
|
|
Archives of Pharmacal Research
1992 Volume.15 No. 3 p.208 ~ p.210
|
|
|
Relative Bioavailability Studies on Two Tablet Preparations of Ofloxacin
|
|
Shakya AK
Talwar N/Karajgi J/Singhai A
|
|
|
Abstract
|
|
|
|
Comparative bioavailability of two tablet dosage forms of ofloxacin (either as Hoechst (India) or Ranbaxy preparation) was investigated. In a randomized cross-over study, eight healthy human volunteers received single 200mg dose of film coated ofloxacin in fasting state. The concentrations of ofloxacin in the collected saliva and serum samples were measured by high performance liquid chromatography. No significant difference in bioavailability of both preparations was judged from various serum and saliva pharmacokinetic parameters such as peak concentration, time to peak concentration and area under the curves. Intersubject variation was also found to be insignificant.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|